In a post-hoc analysis, LIPITOR 80 mg reduced the incidence of ischemic stroke(218/2365, % vs. 274/2366, %) and increased the incidence of hemorrhagic stroke (55/2365, % vs. 33/2366, %)compared to placebo. The incidence of fatal hemorrhagic stroke was similar between groups (17LIPITOR vs. 18placebo). The incidence of non-fatal hemorrhagic strokes was significantly greater in the atorvastatin group (38 non-fatal hemorrhagic strokes) as compared to the placebo group (16 non-fatal hemorrhagic strokes). Subjects who entered the study with a hemorrhagic stroke appeared to be at increased risk for hemorrhagic stroke [7 (16%) LIPITOR (4%) placebo].
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