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Much of the variation in tasting of PTC is associated with polymorphism at the TAS2R38 taste receptor gene. [11] In humans, there are three SNPs ( single nucleotide polymorphisms ) along the gene that may render its proteins unresponsive. [12] There is conflicting evidence as to whether the inheritance of this trait is dominant or incompletely dominant . [2] Any person with a single functional copy of this gene can make the protein and is sensitive to PTC. [ citation needed ] Some studies have shown that homozygous tasters experience a more intense bitterness than people that are heterozygous ; other studies have indicated that another gene may determine taste sensitivity. [1]

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