The partition coefficient of the ester in question is important because is effects how long the drug itself stays in the system. If the testosterone transfers too quickly from the oil to the blood, the result is a sudden spike in testosterone which then rapidly drops once the dose has been used up. In the example of free testosterone injected into the muscle from a water suspension (as in Aquiviron, mentioned above), the testosterone is essentially immediately available to the bloodstream due to its low partition coefficient, and thus there is an immediate spike of testosterone which is used up quickly in the body.
Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use CLOBEX® Shampoo (clobetasol propionate shampoo) for a condition for which it was not prescribed. Do not give CLOBEX® Shampoo (clobetasol propionate shampoo) to other people, even if they have the same symptoms you have. It may harm them. This leaflet summarizes the most important information about CLOBEX® Shampoo (clobetasol propionate shampoo) . If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information about CLOBEX® Shampoo (clobetasol propionate shampoo) that is written for health professionals.