A 2016 phase 1–2 prospective study orally administered 800 mg per day to 27 patients with telomere diseases. The primary efficacy endpoint was a 20% reduction in the annual rate of telomere attrition measured. Toxic effects formed the primary safety endpoint. The study was halted early, after telomere attrition was reduced in all 12 patients who could be evaluated. 12 of 27 patients achieved the primary efficacy end point, 11 of whom increased telomere length at 24 months. Hematologic responses (secondary efficacy endpoint) occurred in 10 of 12 patients who could be evaluated at 24 months. Elevated liver-enzyme levels and muscle cramps (known adverse effects) of grade 2 or less occurred in 41% and 33% of the patients, respectively. 
Aldactone is a very effective diuretic. Many performance athletes often assume it’s weak but this is normally due to a misguided assumption pertaining to their own physique. If you are truly in shape and use this diuretic, such as a competitive bodybuilder, you will appear sharper once you hit the stage. If you do not appear noticeably sharper, this simply means you were fatter than you thought. As a therapeutic diuretic, you will also find Aldactone is far more comfortable than other options, but in severe cases of hypertension and edema it’s sometimes not enough. However, there is no reason a healthy athlete should really ever need anything stronger than this diuretic, and this is good news as stronger loop-diuretics can be very damaging to the athlete’s health.
Drugs can be added and removed from this list by WADA annually, although not all of the banned substances are explicitly named. Caroline Hatton, PhD , a sports anti-doping science consultant, told in a Mar. 12, 2010 email that "A key concept in prohibited lists is that they avoid being finite. Instead of listing all banned drugs one by one, they list entire drug classes and name drugs merely as examples. This is to keep users who took designer drugs from claiming that they didn't break the rules because the drugs they took weren't listed."