A lot depends on where the LS is! I had it around the rectum quite badly, the typical keyhole shape described in many articles, so I had to use it there. The splitting and fissures I had healed well. However I have to be really careful not to let dermovate near my ureathra as it makes me very sore. Nowadays I usually get on fine with daily applications of 1% hydrocortisone, but last week for the first time in two years I had to use dermovate for three days and it felt like I had a UTI. I think experience will be your best guide
Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A 2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor , arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
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