What is fluticasone propionate nasal spray usp used for

A twelve month study (Gaining Optimal Asthma ControL, GOAL), in 3416 adult and adolescent patients with persistent asthma, compared the safety and efficacy of Seretide versus inhaled corticosteroid (Fluticasone Propionate) alone to determine whether the goals of asthma management were achievable. Treatment was stepped up every 12 weeks until ** total control was achieved or the highest dose of study drug was reached. GOAL showed more patients treated with Seretide achieved asthma control than patients treated with ICS alone and this control was attained at a lower corticosteroid dose.

No metabolites of fluticasone propionate were detected in an in vitro study of radiolabeled fluticasone propionate incubated in a human skin homogenate. The total blood clearance of systemically absorbed fluticasone propionate averages 1,093 mL/min (range, 618 to 1,702 mL/min) after a 1-mg intravenous dose, with renal clearance accounting for less than % of the total. Fluticasone propionate is metabolized in the liver by cytochrome P450 3A4-mediated hydrolysis of the 5- fluoromethyl carbothioate grouping. This transformation occurs in 1 metabolic step to produce the inactive17-ß-carboxylic acid metabolite, the only known metabolite detected in man. This metabolite has approximately 2,000 times less affinity than the parent drug for the glucocorticoid receptor of human lung cytosol in vitro and negligible pharmacological activity in animal studies. Other metabolites detected in vitro using cultured human hepatoma cells have not been detected in man.

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The most common side effects associated with fluticasone are headache , throat infection, nasal irritation, sneezing , cough , nausea , vomiting . Hypersensitivity reactions such as skin rash , itching , facial swelling, and anaphylaxis may occur. Some children may experience growth suppression when using fluticasone. A bloody nasal discharge ( nosebleed ) and septum perforation may occur. Fungal infection of the nose and throat, glaucoma , and cataracts are also associated with intranasal fluticasone.

What is fluticasone propionate nasal spray usp used for

what is fluticasone propionate nasal spray usp used for

The most common side effects associated with fluticasone are headache , throat infection, nasal irritation, sneezing , cough , nausea , vomiting . Hypersensitivity reactions such as skin rash , itching , facial swelling, and anaphylaxis may occur. Some children may experience growth suppression when using fluticasone. A bloody nasal discharge ( nosebleed ) and septum perforation may occur. Fungal infection of the nose and throat, glaucoma , and cataracts are also associated with intranasal fluticasone.

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